We used hetero‐ and homozygous R349P desmin... Background Jede Zelle besitzt ein verzweigtes Netzwerk von... Muskelkraft und -bewegung beruhen auf molekularen Prozessen in den kontraktilen Bausteinen der Muskelzellen, den Sarkomeren. Im Profil von Wolfgang Link sind 5 Jobs angegeben. -Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modelling, drug screening, and heart repair. Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Wolfgang Link und Jobs bei ähnlichen Unternehmen erfahren. Bar graphs represent the mean ± SEM of splenic (A) CCR2, (B) MCP-1, (C) CX3CR1, and (D) CX3CL1 gene expression, as indicated, after normalization to the housekeeping gene 18S using the 2−ΔCt formula and normalized to the WT group, wh... Heterozygous variants in BICD cargo adapter 2 (BICD2) cause autosomal dominant spinal muscular atrophy, lower extremity-predominant 2 (SMALED2). The relationship between oxidative stress and cardiac stiffness is thought to involve modifications to the giant muscle protein titin, which in turn can determine the progression of heart disease. Es gibt 30+ Personen namens „Wolfgang Link“, die LinkedIn zum Austausch von Informationen, Ideen und Karrierechancen nutzen. Elevating NAD ⁺ by oral supple... Striated muscle responds to mechanical overload by rapidly up-regulating the expression of the cardiac ankyrin repeat protein, CARP, which then targets the sarcomere by binding to titin N2A in the I-band region. Aging is associated with an increased risk of cardiovascular disease and death. Im Wintersemester 1921/22 wurde Pauli planmässiger Assistent von Professor Max Born (Link verlässt diese Seite).Born kehrte in diesem Jahr an seine Alma Mater zurück, an der er sich bereits 1909 habilitiert hatte. The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein titin, which is a scaffolding filament, signaling platform, and provider of passive tension and elasticity in myocytes. Crucial role of protein kinase G in regulating Ca2(+)/calmodulin-dependent protein kinase-II activity and oxidative stress: The diastolic function modulation via PKG-dependent CaMKII phosphorylation and oxidation. Here, we characterise the molecular stru... Background To expand the spectrum of bicaudal D, Drosophila, homologue 2 (BICD2) gene-related diseases, which so far includes autosomal dominant spinal muscular atrophy with lower extremity predominance 2 and hereditary spastic paraplegia due to mutations in the BICD2 gene. Due to our privacy policy, only current members can send messages to people on ResearchGate. Wolfgang. Indeed, there is a tight link in terms of shared risk factors and mechanisms... AimsOur aim was to investigate the effect of nitric oxide (NO)-independent activation of soluble guanylyl cyclase (sGC) on cardiomyocyte function in a hypertensive animal model with diastolic dysfunction and in biopsies from human heart failure with preserved ejection fraction (HFpEF).Methods More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction (HFpEF) associated with type-2 diabetes mellitus (T2DM). Wolfgang Rode Innenarchitekt in Göttingen im Branchenbuch von meinestadt.de - Telefonnummer, Adresse, Stadtplan, Routenplaner und mehr für Wolfgang Rode Innenarchitekt Göttingen Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. : You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. 1985 - 1989: ... A current and ongoing project is to link invariants from low-dimensional topology such as the Thurston norm and the Thurston polytope to generalized -torsion invariants. • The extent of myocardial fibrosis and the degree of isoform-expression and phosphorylation changes in cardiomyocyte titin were unknown in different hemodynamic subgroups of AS, including “paradoxical” low-flow, low-gradient AS with preserved ejection fraction. Academician at Göttingen Academy of Sciences, Fellow of the International Society for Heart Research (ISHR), Franz Maximilian Groedel Research Prize of the German Cardiac Society, Heisenberg Fellowship from German Research Foundation. agric. Working Group "Breeding Research Faba Bean" Vicia faba L. is a partially allogamous plant, with an intermediate level of cross- and of self-fertilization, realized by honey and bumble bees. Dort erfahren Sie auch die vollständige Adresse von Link Wolfgang Dr. in Göttingen-Groß Ellershausen, um Post dorthin zu schicken. Voges, 2007: Genetische Analyse von Heterosis im jüngsten Stadium einer Pflanze, als Embryo, am Beispiel der Fababohne (, Franziska Roth, 2010: Evaluierung von Winterackerbohnen als Zwischenfrucht für eine ökologische Biogasproduktion. Here, we use a novel titin-cleavage (TC) mouse model that allows specific and rapid cutting of elastic titin to quantify how titin-based forces define myocyte ultrastructure and mechanics. Richtige Adressen und Telefonnummern finden! The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (Fpassive) of cardiomyocytes. Wolfgang König hat die Professur für Betriebswirtschaftslehre, insbesondere Wirtschaftsinformatik und Informationsmanagement an der Goethe-Universität Frankfurt inne. Coxsackievirus B3 (CVB3)-induced myocarditis is associated with severe cardiac inflammation, which may progress to heart failure. Dezember 2015 in Lenglern) war ein deutscher Arzt und Hochschullehrer. nach Vereinbarung. To date, the role of this interaction in the stress response of muscle remains poorly understood. Cuvillier Göttingen (in Zusammenarbeit mit. Die Staatsanwaltschaft Göttingen sieht mit Blick auf die Akten über „Linksmotivierte“ keinen Anfangsverdacht bei Mitarbeitern des Göttinger Staatsschutzes. Rudolf-Schwander-Str. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). E-Mail: dialog@vobakg.de . All rights reserved. Sehen Sie sich das Profil von Wolfgang Link im größten Business-Netzwerk der Welt an. Wolfgang Victor Ruttkowski is a scholar of literature and culture. Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy, Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes, The Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Membrane Remodeling by a Bacterial Phospholipid-Methylating Enzyme, Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair, Mechanically Unfolded Titin Immunoglobulin Domains Refold Faster and More Accurately in Presence of Chaperone Alpha-B-Crystallin, A Multi-Tool Mouse Model to Study the Elasticity of Native Titin, Dietary spermidine for lowering high blood pressure, Titin-truncating variants affect heart function in disease cohorts and the general population, Cardioprotection and lifespan extension by the natural polyamine spermidine, Expanding the phenotype of BICD2 mutations toward skeletal muscle involvement, Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection FractionClinical Perspective, Developmental Basis of Cardiac Inherited Diseases470Extracardiac endothelium patterns embryonic coronary arterio-venous connections471DCM-associated RBM20-mutations lead to aberrant splicing of titin and ryanodin receptor 2 in the human myocardium472The impact of missense versus nonsense mutations in arrhythmogenic cardiomyopathy phenotype, Expression and function of dipeptidyl peptidases. Loslösung von Myosin-Querbrücken immer wiede... Several studies have demonstrated that administration of doxorubicin (DOXO) results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopathies and cardiomyopathies with marked clinical variability. We analyzed 2 independent German families with clinical, geneti... Background: Concentric hypertrophy following pressure-overload is linked to preserved systolic function but impaired diastolic function, and is an important substrate for heart failure with preserved ejection fraction. Methods Max Planck Institute for Solar System Research. Erstes Album [wolf:gang] 25.08.18 Mitochondrial function is critically dependent on the folding of the mitochondrial inner membrane into cristae; indeed, numerous human diseases are associated with aberrant crista morphologies. Experimental data indicate that stimulation of the nitric oxide-soluble guanylate cyclase(sGC)-cGMP-PKG pathway can increase left ventricular (LV) capacitance via phosphorylation of the myofilamental protein titin. With the MICOS complex, OPA1 and the F 1 F o -ATP synthase, key players of cristae bio … Die Aktin- und Myosinfilamente treten durch Bildung bzw. Cuvillier Verlag Göttingen. Universität Göttingen. Wolfgang. Reminiscent of Myo18b, Myo18a was highly exp... Cardiac functionality is dependent on a balanced protein turnover. Sorry, you need to be a researcher to join ResearchGate. Die Universitätsmedizin Göttingen (UMG) ist Ihr Ansprechpartner für medizinische Versorgung, Lehre und Forschung auf höchstem Niveau. E-Mail: neurologie.sekretariat(at)med.uni … Mustapha Arbaoui, 2007: Detailed genetic analysis of faba bean, Lamiae Ghaouti, 2007: Comparison of pure line cultivars with synthetic cultivars in local breeding of faba bean (, Susanne Dieckmann geb. Kontakt: Telefon: 0551/400-4561 Telefax: 0551/400-4580 E-Mail: w.steinmetzer@goettingen.de Raum: 110 ZUR ÜBERSICHT. Diese Bewegungen werden durch spezielle Struktur- und Motorproteine in den Muskelzellen ermöglicht. However, testing these mechanical hypotheses on native molecules in their natural environment remains inaccessible to conventional genetics, biophysics and molecular biology tools. The established viral model system enables a dose-dependent and highly localized RNA-virus expression in a fully... Filamin C (FLNc) is mainly expressed in striated muscle cells where it localizes to Z-discs, myotendinous junctions and intercalated discs. We evaluated adaptations in myocardial stiffness due to acute stretching and characterized the underlying mechanisms. : 0561 7893-0. University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. Webseiten der Georg-August-Universität Göttingen. Join ResearchGate to contact this researcher and connect with your scientific community. Wolfgang Wucherpfennig ist Bürgermeister der Samtgemeinde Radolfshausen.Er wurde am 12. MPS develops and builds scientific instruments that investigate solar system bodies. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD ⁺ ). Accordingly, regulated protein decay is critical to maintain cardiac function. Traditional force spectroscopy of titin can study only eight tandem Ig domains at a time, and the dominant 96 Einträge zu Wolfgang Link mit aktuellen Kontaktdaten, Öffnungszeiten und Bewertungen ☎ Das Telefonbuch - Ihre Nr. 34117 Kassel . We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with a dilated cardiomyopathy (DCM) mutation, troponin T (TnT)-R173W, display sarcomere protein mi... Dysfunctional high-density lipoprotein (d-HDL) in chronic kidney disease is known to have a change in composition towards an endothelial-damaging phenotype, amongst others, via the accumulation of symmetric dimethylarginine. However, testing these mechanical hypotheses on proteins in their natural environment remains inaccesible to conventional tools. This file is licensed under the Creative Commons Attribution 3.0 Unported license. We hypothesized that diminished LA compliance and contractile function occur early during the development of heart failure with preserved ejection fraction (HFpEF) and impair overall cardiac performance. The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage in sepsis. Bei Vielzellern sind die Skelettmuskeln für die Fortbewegung zuständig. Mutations in the gene encoding for titin (TTN) are the leading known cause of familial dilated cardiomyopathy. Erstes Album [wolf:gang] 25.08.18 März 1949 geboren.
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